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Shaking the vial creates shearing forces that can physically break the delicate amino acid bonds of the peptide, a process called denaturation
Drucker and Habener showed that small quantities of laboratory-synthesized GLP-1 could trigger insulin
Integrative cancer therapies
Examples include self-assembling peptide systems for controlled release and implantable long-duration semaglutide devices [21, 10]
One of those assigned to work on GLP-1 at Novo Nordisk was Lotte Bjerre Knudsen (figure 37), a young researcher hired by the company in 1989 straight after she completed her chemistry training at the Technical University of Denmark
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